Understanding of Molecular Pain Medicine: Genetic Basis of Variation in Pain Sensation and Analgesia Response

Beyond Sensation: Exploring the Molecular and Genetic Basis for Pain

P 79: Neuroinflammation: A Common Phenomenon between Chronic Pain and Opioids

Chronic pain is a prevalent and debilitating condition, conveying immense human burden. Suffering from chronic pain is not only caused by painful symptomatology, but also through a wide range of psychopathological and physical consequences, including depression and anxiety disorders, impaired sleep and cognition, cardiovascular morbidity and impaired sexual function, all contributing to diminis...

Effects of intrathecal administration of genipin on pain and morphine induced analgesia in rats

Introduction: Uncoupling protein 2 (UCP2) in the inner mitochondrial membrane changes the activity of KATP channels and the cell excitability, probably by decreasing the ATP production. Given the expression of UCP2 in primary afferent neurons, and the importance of these channels in morphine-induced analgesia, genipin, an UCP2 inhibitor, may affect these processes, when administrated intrath...

Evaluation of Palmar Digital Nerve Block and Distal Interphalangeal Joint Analgesia in Lame Horses Associated with Hoof Pain due to Sidebone Fracture

Objective- To determine if the pain of the third phalanx due to sidebone fracture in horses can be attenuated by analgesia of the distal interphlangeal joint and palmar digital nerve block. Design- Clinical study. Animals- Seven horses with unilateral forelimb lameness associated with hoof pain due to sidebone fracture. Procedures- Seven mix breed show jumping horses were selected from hor...

Assessment of Pain Management in Pediatric Emergency Department in Mashhad -Iran

Introduction: Pain may be described as a sensation of hurt or strong discomfort and is the body's way of sending message to the brain that an injury has occurred. Pain medicines block these messages or reduce their effect on the brain. Accurate administration of analgesia have a long –lasting effect on children whole experience of medical care and affects parents' and children's future reaction...